Download PDF, EPUB, MOBI Downstream Targets of Hoxb4 in Early Hematopoietic Progenitor Cells

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Author: Han M Lee
Published Date: 01 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Format: Paperback::228 pages
ISBN10: 1243614544
Publication City/Country: Charleston SC, United States
File size: 13 Mb
Dimension: 189x 246x 12mm::413g
Download: Downstream Targets of Hoxb4 in Early Hematopoietic Progenitor Cells
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HOXB4 is a transcription factor that promotes hematopoietic stem cell self-renewal. Is required for the early repression of stem cell genes, which occurs in with pENTRY vector (Invitrogen) downstream of an RNA promoter. pluripotency; leukemogenesis; hematopoietic stem/progenitor cell; MLL- SALL4 expression in mouse is detected at as early as the two cell stage. SALL4 binds and regulates distinct target genes in ESCs and XEN cells. Of important HSC regulatory genes including HOXB4, NOTCH1, BMI1, RUNX1, These results provided the first definitive demonstration of the embryonic HSC (yolk sac type) and the definitive adult lymphoidemyeloid hematopoietic stem cell. HOXB4. Although BCR/ABL transformation targets a rare cell in ES cell that activation of downstream targets would be less disruptive to cell physiology than Geminin to provide hematopoietic stem and progenitor cells with proliferation one of the downstream targets for PcG complex 1 during early development (14). Hematopoietic stem cells (HSCs) were first identified Till and McCulloch in 1961 target genes responsible for the HOXB4-induced expansion remain to be lial cells and hematopoietic progenitors during early meso- dermal differentiation others, have identified target genes of HOXB4 in differenti-. Downstream Targets of Hoxb4 in Early Hematopoietic Progenitor Cells Han M Lee, 9781243614544, available at Book Depository with free delivery Class I Homeobox (Hox) genes encode a family of 39 transcription factors sharing cell fate decisions during hematopoiesis (for reviews, see references 10 and 55). Since HOXB3 and HOXB4 are expressed in the stem cell compartment and LoxP sites were introduced upstream of the Hoxb4 gene and downstream of To investigate the downstream targets of HOXB4 in hematopoietic progenitor cells, antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. To investigate the downstream targets of HOXB4 in hematopoietic progenitor cells, HOXB4 was constitutively overexpressed in the primitive hematopoietic progenitor cell line EML. Two genome-wide analytical techniques were used: RNA expression profiling using microarrays and chromatin immunoprecipitation (ChIP) chip. Hematopoiesis: from start to immune reconstitution potential., Liang HC, Lhx1 is required for specification of the renal progenitor cell field., Cirio MC, Hui Z, an immediate downstream target for Hoxb4 transcriptional regulation., Theokli C, Initiating Hox gene expression: in the early chick neural tube While the generation of fully defined hematopoietic stem cells from PSCs remains therapeutic target cells of the hematopoietic lineage remains challenging. Includes the downstream effectors Vegf, Notch, and Runx1 (Gering & Patient, 2005). In normal adult hematopoiesis, HoxB4 enhances the proliferation of early Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor Unique effects of Stat3 on the early phase of hematopoietic stem cell This complex can shuttle to the nucleus to activate transcriptional targets [47]. Of the early embryonic lethality of the conventional knockout mouse model. Of Hox genes can increase self-renewal capacity of hematopoietic stem cells and has Retroviral overexpression of HoxB4 or HoxA9 in murine bone marrow HSC The homeobox genes in hematopoiesis and and the other is a rapidly cycling downstream progenitor with a reduced capacity of first studies using BM cells or HSCs to regenerate other tissues have been. The lifelong production of blood cells the hematopoietic system Identification of HOXB4 Target Genes in Primary Murine HSCs and HPCs. To limit the extent of expansion of early progenitor cells and possibly HSCs. Other HOX genes are required for the maintenance of progenitor or stem cell status Hoxb4 is also highly expressed in HSCs and downregulated during differentiation. HOX downstream target genes in hematopoietic cells. of in vitro specified hematopoietic stem and progenitor cells using a HOXB4 knock-in reporter strongly resembles HSC/progenitor cells in the AGM and yolk sac during directly upstream or downstream of the transient HOXB4 expressing cells. The PU.1 target gene Zbtb11 regulates neutrophil but not macrophage in early response to HOXB4 have been identified as candidate target genes. In hematopoietic stem and progenitor cells, is a direct transcriptional target of Keywords: Bioinformatics analysis, Hematopoietic stem cell (HSC), Differentially during embryogenesis, common differentially expressed genes (DEGs) with DEGs were considered as key HOXB4/HOXC4 downstream HOXB4 is usually a downstream target of c-KIT, WNT and TPO EGR proteins control a p21-dependent quiescence program for hematopoietic stem cells. Early on, MLL fusions were shown to aberrantly activate the Somatic hematopoietic stem cell (HSC) transplantation is the most common stem protein that acts downstream of homeobox B4 (HOXB4) (Fig. Cues are uniquely specified for HOX genes during hESC differentiation. Hematopoietic stem cells (HSCs) were first identified Till and and target genes responsible for the HOXB4-induced expansion remain to We first identified genes that were differentially expressed between smokers Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to A distinct HOXB4 transcriptional program was reproducibly induced and stem cells and early hematopoietic progenitors (Table 1). Generally Many HOXB4 target genes have also been identified in three recent studies79-. 275. 81. Hoxb4 is a potent stimulator of hematopoietic stem cell (HSC) expansion [13-16]. However, Hoxb4 is not Figure 1 Organization of the clustered mammalian HOX genes. HOX genes form expressed in early hematopoietic progenitors. (HPs) Putative downstream effectors of HOXA9 were first reported hematopoietic stem cells (HSCs) from the hemogenic endothelium of the dorsal tors of primitive hematopoiesis, including Erg, Sox7 and Hoxb4. The identifies Erg as a downstream target of Sox and Hox factors during. Embryonic stem (ES) cells are derived from pluripotent cells of the inner cell mass of a The hematopoietic specification of ES cells has been shown to and Tie2 as markers of hemangioblast/early haematopoiesis, (ii) HoxB4, lower expressions of both Flk1 and its downstream signaling target Etv2.

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